Stereochemical Determination of Thuggacins A–C, Highly Active Antibiotics from the Myxobacterium <i>Sorangium cellulosum</i>

Abstract

Chemistry and biology meet in the structure elucidation of the antibiotics thuggacins A–C. The absolute configuration of all stereogenic centers in the thuggacins was confirmed through a combination of chemical derivatization, NMR analysis, molecular modeling, and bioinformatic analysis of the thuggacin biosynthetic genes. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704897_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.