Two novel plasmid-mediated cefotaxime-hydrolyzing β-lactamases (CTX-M-5 and CTX-M-6) from<i>Salmonella typhimurium</i>
Maria Gazouli(Pasteur Hellenic Institute), Εva Tzelepi(Pasteur Hellenic Institute), Antonios Markogiannakis(National and Kapodistrian University of Athens), N.J. Legakis(National and Kapodistrian University of Athens), L. S. Tzouvelekis(National and Kapodistrian University of Athens)
Cited by 65
Abstract
Two novel plasmid-mediated beta-lactamases (CTX-M-5 and CTX-M-6) produced by Salmonella typhimurium clinical strains were characterized. The enzymes exhibited a pI of 8.4, hydrolyzed oxyimino-beta-lactams and were susceptible to mechanism-based beta-lactamase inhibitors. The respective bla genes were cloned and sequenced. The deduced amino acid sequences showed a high degree of homology with those of the previously described plasmid class A CTX-M-type enzymes and appeared related to the chromosomal beta-lactamases of Klebsiella oxytoca.
Related Papers
No related papers found
Powered by citation graph analysis