The Challenge of Finding a Cure for HIV Infection
Douglas D. Richman(University of North Carolina at Chapel Hill), David M. Margolis(University of North Carolina at Chapel Hill), Martin Delaney(University of North Carolina at Chapel Hill), Warner C. Greene(University of North Carolina at Chapel Hill), Daria J. Hazuda(University of North Carolina at Chapel Hill), Roger J. Pomerantz(University of North Carolina at Chapel Hill)
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Abstract
Although combination therapy for HIV infection represents a triumph for modern medicine, chronic suppressive therapy is required to contain persistent infection in reservoirs such as latently infected CD4+ lymphocytes and cells of the macrophage-monocyte lineage. Despite its success, chronic suppressive therapy is limited by its cost, the requirement of lifelong adherence, and the unknown effects of long-term treatment. This review discusses our current understanding of suppressive antiretroviral therapy, the latent viral reservoir, and the needs for and challenges of attacking this reservoir to achieve a cure.
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