A New and Known Cytotoxic Aryltetralin-Type Lignans from Stems of Bursera graveolens
Tsutomu Nakanishi(Setsunan University), Yuka Inatomi(Setsunan University), Hiroko Murata(Setsunan University), Kaori Shigeta(Setsunan University), Naoki Iida(Setsunan University), Akira Inada(Setsunan University), Jin Murata(Tokyo University of Science), Miguel Ángel Pérez‐Farrera, Munekazu Iinuma(Gifu Pharmaceutical University), Toŝhiyuki Tanaka(Gunma Prefectural Institute of Public Health and Environmental Sciences), Shogo Tajima(University of Shizuoka), Naoto Oku(University of Shizuoka)
Cited by 33Open Access
Abstract
A new 4alpha-aryltetralin-type lignan called burseranin (1) and a known analogous lignan picropolygamain (2) were isolated along with known triterpenes, lupeol and epi-lupeol from the methanol extract of stems of Bursera graveolens, which showed a remarkable inhibitory activity against human HT1080 fibrosarcoma cells. The whole structure of 1 was established based on combined spectral studies and the absolute structure for 2 was first confirmed by CD spectral evidence. In addition, cytotoxic activities of the stem (methanol) extract and its components are evaluated in this paper.
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