InterPro: the integrative protein signature database

Sarah Hunter(University Hospital Heidelberg), Rolf Apweiler(Centre National de la Recherche Scientifique), Teresa K. Attwood(Centre National de la Recherche Scientifique), Amos Bairoch(Heidelberg University), Alex Bateman(University Hospital Heidelberg), David Binns(University Hospital Heidelberg), Peer Bork(Georgetown University), Ujjwal Das(University College London), Louise C. Daugherty(Georgetown University), L. Duquenne(European Bioinformatics Institute), ROBERT FINN(Wellcome Sanger Institute), Julian Gough(University College London), Daniel H. Haft(Centre National de la Recherche Scientifique), Nicolas Hulo(Wellcome Sanger Institute), Daniel Kahn(Heidelberg University), Elizabeth A. Kelly(University Hospital Heidelberg), Aurélie Laugraud(SIB Swiss Institute of Bioinformatics), Ivica Letunić(Wellcome Sanger Institute), D. Lonsdale(Centre National de la Recherche Scientifique), Rodrigo López(Université Claude Bernard Lyon 1), Martin Madera(University Hospital Heidelberg), John Maslen(University Hospital Heidelberg), Craig McAnulla(Centre National de la Recherche Scientifique), J. McDowall(University Hospital Heidelberg), Jaina Mistry(University College London), Alex Mitchell(SIB Swiss Institute of Bioinformatics), Nicola Mulder(European Bioinformatics Institute), Darren A. Natale(Heidelberg University), C. Orengo(SIB Swiss Institute of Bioinformatics), A. F. Quinn(SIB Swiss Institute of Bioinformatics), J. D. Selengut(University Hospital Heidelberg), Christian J A Sigrist(Wellcome Sanger Institute), Manjula Thimma(European Bioinformatics Institute), Paul D. Thomas(University Hospital Heidelberg), F. Valentin(Wellcome Sanger Institute), Derek A. Wilson(Wellcome Sanger Institute), Cathy Wu(Heidelberg University), Corin Yeats(University Hospital Heidelberg)
Nucleic Acids Research
October 21, 2008
10.1093/nar/gkn785
Cited by 2,147Open Access
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Abstract

The InterPro database (http://www.ebi.ac.uk/interpro/) integrates together predictive models or 'signatures' representing protein domains, families and functional sites from multiple, diverse source databases: Gene3D, PANTHER, Pfam, PIRSF, PRINTS, ProDom, PROSITE, SMART, SUPERFAMILY and TIGRFAMs. Integration is performed manually and approximately half of the total approximately 58,000 signatures available in the source databases belong to an InterPro entry. Recently, we have started to also display the remaining un-integrated signatures via our web interface. Other developments include the provision of non-signature data, such as structural data, in new XML files on our FTP site, as well as the inclusion of matchless UniProtKB proteins in the existing match XML files. The web interface has been extended and now links out to the ADAN predicted protein-protein interaction database and the SPICE and Dasty viewers. The latest public release (v18.0) covers 79.8% of UniProtKB (v14.1) and consists of 16 549 entries. InterPro data may be accessed either via the web address above, via web services, by downloading files by anonymous FTP or by using the InterProScan search software (http://www.ebi.ac.uk/Tools/InterProScan/).

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