Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

Kristen N. Stevens(Mayo Clinic), Celine M. Vachon(Mayo Clinic), Adam M. Lee(Mayo Clinic), Susan Slager(Mayo Clinic), Timothy G. Lesnick(Mayo Clinic), Curtis Olswold(Mayo Clinic), Peter A. Fasching(Mayo Clinic), Penelope Miron(Mayo Clinic), Diana Eccles(Mayo Clinic), Jane Carpenter(Mayo Clinic), Andrew K. Godwin(Mayo Clinic), Christine B. Ambrosone(Mayo Clinic), Robert Winqvist(Mayo Clinic), Hiltrud Brauch(Mayo Clinic), Marjanka K. Schmidt(Mayo Clinic), Angela Cox(Mayo Clinic), Simon S. Cross(Mayo Clinic), Elinor J. Sawyer(Mayo Clinic), Arndt Hartmann(Mayo Clinic), Matthias W. Beckmann(Mayo Clinic), Rüdiger Schulz-Wendtland(Mayo Clinic), Arif B. Ekici(Mayo Clinic), William Tapper(Mayo Clinic), Susan M. Gerty(Mayo Clinic), Lorraine Durcan(Mayo Clinic), Nikki Graham(Mayo Clinic), Rebecca Hein(Mayo Clinic), Stephan Nickels(Mayo Clinic), Dieter Flesch‐Janys(Mayo Clinic), Judith Heinz(Mayo Clinic), Hans‐Peter Sinn(Mayo Clinic), Irene Konstantopoulou(Mayo Clinic), Florentia Fostira(Mayo Clinic), Dimitrios Pectasides(Mayo Clinic), Athanasios M. Dimopoulos(Mayo Clinic), George Fountzilas(Mayo Clinic), Christine L. Clarke(Mayo Clinic), Rosemary L. Balleine(Mayo Clinic), Janet E. Olson(Mayo Clinic), Zachary Fredericksen(Mayo Clinic), Robert B. Diasio(Mayo Clinic), Harsh B. Pathak(Mayo Clinic), Eric A. Ross(Mayo Clinic), JoEllen Weaver(Mayo Clinic), Thomas Rüdiger(Mayo Clinic), Asta Försti(Mayo Clinic), Thomas Dünnebier(Mayo Clinic), Foluso O. Ademuyiwa(Mayo Clinic), Swati Kulkarni(Mayo Clinic), Katri Pylkäs(Mayo Clinic), Arja Jukkola‐Vuorinen(Mayo Clinic), Yon‐Dschun Ko(Mayo Clinic), Erik Van Limbergen(Mayo Clinic), Hilde Janssen(Mayo Clinic), Julian Peto(Mayo Clinic), Olivia Fletcher(Mayo Clinic), Graham G. Giles(Mayo Clinic), Laura Baglietto(Mayo Clinic), Senno Verhoef(Mayo Clinic), Ian Tomlinson(Mayo Clinic), Veli‐Matti Kosma(Mayo Clinic), Jonathan Beesley(Mayo Clinic), Dario Greco(Mayo Clinic), Carl Blomqvist(Mayo Clinic), Astrid Irwanto(Mayo Clinic), Jianjun Liu(Mayo Clinic), Fiona M. Blows(Mayo Clinic), Sarah‐Jane Dawson(Mayo Clinic), Sara Margolin(Mayo Clinic), Arto Mannermaa(Mayo Clinic), Nicholas G. Martin(Mayo Clinic), Grant W. Montgomery(Mayo Clinic), Diether Lambrechts(Mayo Clinic), Isabel dos‐Santos‐Silva(Mayo Clinic), Gianluca Severi(Mayo Clinic), Ute Hamann(Mayo Clinic), Paul D.P. Pharoah(Mayo Clinic), Douglas F. Easton(Mayo Clinic), Jenny Chang‐Claude(Mayo Clinic), Drakoulis Yannoukakos(Mayo Clinic), Heli Nevanlinna(Mayo Clinic), Xianshu Wang(Mayo Clinic), Fergus J. Couch(Mayo Clinic)
Cancer Research
August 15, 2011
10.1158/0008-5472.can-11-1266
Cited by 121Open Access
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Abstract

Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.

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