Mutual Antagonism of T Cells Causing Psoriasis and Atopic Eczema

Stefanie Eyerich(Helmholtz Zentrum München), Anna Theresa Onken(Technical University of Munich), Stephan Weidinger(University of Lübeck), André Franke(University of Lübeck), Francesca Nasorri(Istituto Dermopatico dell'Immacolata), Davide Pennino(Helmholtz Zentrum München), Martine Grosber(Technical University of Munich), Florian Pfab(Technical University of Munich), Carsten B. Schmidt‐Weber(Helmholtz Zentrum München), Martin Mempel(Universitätsmedizin Göttingen), Ruediger Hein(Technical University of Munich), Johannes Ring(Technical University of Munich), Andrea Cavani(Istituto Dermopatico dell'Immacolata), Kilian Eyerich(Technical University of Munich)
New England Journal of Medicine
July 20, 2011
10.1056/nejmoa1104200
Cited by 228Open Access
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Abstract

The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and
\ntype 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2)
\ncells is rare. Here, we describe three patients with co-occurring psoriasis and atopic
\neczema with an antagonistic course and distinct T-cell infiltrates in lesions from
\npsoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction
\nto epicutaneous allergen challenge, with clinically and histologically verified
\neczema lesions containing a large number of allergen-reactive T cells. These findings
\nsupport a causative role for T cells triggered by specific antigens in both psoriasis
\nand atopic eczema.

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