Genome Sequence of an Obligate Intracellular Pathogen of Humans: <i>Chlamydia trachomatis</i>

Richard S. Stephens(University of California System), Sue Kalman(University of California System), C. J. Lammel(University of California System), Jun Fan(University of California System), Rekha Marathe(University of California System), L. Aravind(University of California System), Wayne Mitchell(University of California System), Lynn Olinger(University of California System), Roman L. Tatusov(University of California System), Qixun Zhao(University of California System), Eugene V. Koonin(University of California System), Ronald W. Davis(University of California System)
Science
October 23, 1998
10.1126/science.282.5389.754
Cited by 1,576

Abstract

Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.

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