Emergence of Zaire Ebola Virus Disease in Guinea
Sylvain Baize(Apple (Israel)), Delphine Pannetier(Ekaterinburg Research Institute of Viral Infections), Lisa Oestereich(Bernhard Nocht Institute for Tropical Medicine), Toni Rieger(Bernhard Nocht Institute for Tropical Medicine), Lamine Koivogui(Institut National de Santé Publique), N’Faly Magassouba(Institut de Recherche Agronomique de Guinée), Barré Soropogui(Institut de Recherche Agronomique de Guinée), Mamadou Saliou Sow(Donka Hospital), Sakoba Keïta(Institut National de Santé Publique), Hilde De Clerck(Médecins Sans Frontières), Amanda Tiffany(Epicentre (South Africa)), Gemma Domínguez(Médecins Sans Frontières), Mathieu Loua(Ministère de la Santé), Alexis Traoré, Moussa Kolié, Emmanuel Roland Malano(World Health Organization - Pakistan), Emmanuel Heleze(World Health Organization - Pakistan), Anne Bocquin(Ekaterinburg Research Institute of Viral Infections), Stéphane Mély(Ekaterinburg Research Institute of Viral Infections), Hervé Raoul(Ekaterinburg Research Institute of Viral Infections), Valérie Caro, Dániel Cadar(Bernhard Nocht Institute for Tropical Medicine), Martin Gabriel(Bernhard Nocht Institute for Tropical Medicine), Meike Pahlmann(Bernhard Nocht Institute for Tropical Medicine), Dennis Tappe(Bernhard Nocht Institute for Tropical Medicine), Jonas Schmidt‐Chanasit(Bernhard Nocht Institute for Tropical Medicine), Bénido Impouma(World Health Organization - Pakistan), Abdoul Karim Diallo(World Health Organization - Pakistan), Pierre Formenty(World Health Organization - Pakistan), Michel Van Herp(Médecins Sans Frontières), Stephan Günther(Bernhard Nocht Institute for Tropical Medicine)
Cited by 1,384Open Access
Abstract
In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.
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