Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
M.A. Crocq(Centre hospitalier de Rouffach), R. Mant(Centre hospitalier de Rouffach), Philip Asherson(Centre hospitalier de Rouffach), Julie Williams(Centre hospitalier de Rouffach), Yann Hodé(Centre hospitalier de Rouffach), A Mayerová(Centre hospitalier de Rouffach), David Collier(Centre hospitalier de Rouffach), L. Lannfelt(Centre hospitalier de Rouffach), Pierre Sokoloff(Centre hospitalier de Rouffach), J. Schwartz(Centre hospitalier de Rouffach)
Cited by 281Open Access
Abstract
Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).
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