Brønsted Acid Catalyzed Enantioselective Semipinacol Rearrangement for the Synthesis of Chiral Spiroethers

Abstract

A new twist: The catalytic asymmetric semipinacol rearrangement reaction of 2-oxo allylic alcohols 1 in the presence of a catalytic amount of chiral phosphoric acid (R)-2 a or its silver salt (R)-2 b affords enantiomerically pure spiroethers 3. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.