Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery Systems
Norased Nasongkla(The University of Texas Southwestern Medical Center), Erik A. Bey(Advanced Imaging Research (United States)), Jimin Ren(The University of Texas Southwestern Medical Center), Hua Ai(Advanced Imaging Research (United States)), Chalermchai Khemtong(The University of Texas Southwestern Medical Center), Jagadeesh Setti Guthi(The University of Texas Southwestern Medical Center), Shook-Fong Chin(Advanced Imaging Research (United States)), A. Dean Sherry(Advanced Imaging Research (United States)), David A. Boothman(The University of Texas Southwestern Medical Center), Jinming Gao(The University of Texas Southwestern Medical Center)
Cited by 1,233
Abstract
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.
Related Papers
No related papers found
Powered by citation graph analysis