The Transcriptional Program in the Response of Human Fibroblasts to Serum
Vishwanath R. Iyer(Stanford University), Michael B. Eisen(Stanford University), Douglas T. Ross(Stanford University), Greg Schuler(Stanford University), Troy Moore(Stanford University), Jeffrey C. F. Lee(Stanford University), Jeffrey M. Trent(Stanford University), Louis M. Staudt(Stanford University), James R. Hudson(Stanford University), Mark S. Boguski(Stanford University), Deval Lashkari(Stanford University), Dari Shalon(Stanford University), David Botstein(Stanford University), Patrick O. Brown(Stanford University)
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Abstract
The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.
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