Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension
Maurice A. Curtis(University of Auckland), Monica Kam(University of Auckland), Ulf Nannmark(University of Auckland), Michelle F. Anderson(University of Auckland), Mathilda Zetterström Axell(University of Auckland), Carsten Wikkelsø(University of Auckland), S. Holtås(University of Auckland), Willeke van Roon‐Mom(University of Auckland), Thomas Björk‐Eriksson(University of Auckland), Claes Nordborg(University of Auckland), Jonas Frisén(University of Auckland), Michael Dragunow(University of Auckland), Richard L. M. Faull(University of Auckland), Peter S. Eriksson(University of Auckland)
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Abstract
The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.
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