Overview of the<i>CCP</i>4 suite and current developments

Martyn Winn(Daresbury Laboratory), Charles Ballard(Rutherford Appleton Laboratory), Kevin Cowtan(University of York), E.J. Dodson(University of York), Paul Emsley(University of Oxford), Phil Evans(MRC Laboratory of Molecular Biology), Ronan M. Keegan(Rutherford Appleton Laboratory), Eugene Krissinel(Rutherford Appleton Laboratory), Andrew G. W. Leslie(MRC Laboratory of Molecular Biology), Airlie J. McCoy(University of Cambridge), Stuart McNicholas(University of York), Garib N. Murshudov(University of York), Navraj S. Pannu(Leiden University), Elizabeth Potterton(University of York), Harold R. Powell(MRC Laboratory of Molecular Biology), Randy J. Read(University of Cambridge), Alexei A. Vagin(University of York), Keith S. Wilson(University of York)
Acta Crystallographica Section D Biological Crystallography
March 17, 2011
10.1107/s0907444910045749
Cited by 12,516Open Access
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Abstract

The CCP4 (Collaborative Computational Project, Number 4) software suite is a collection of programs and associated data and software libraries which can be used for macromolecular structure determination by X-ray crystallography. The suite is designed to be flexible, allowing users a number of methods of achieving their aims. The programs are from a wide variety of sources but are connected by a common infrastructure provided by standard file formats, data objects and graphical interfaces. Structure solution by macromolecular crystallography is becoming increasingly automated and the CCP4 suite includes several automation pipelines. After giving a brief description of the evolution of CCP4 over the last 30 years, an overview of the current suite is given. While detailed descriptions are given in the accompanying articles, here it is shown how the individual programs contribute to a complete software package.

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