Rhea—a manually curated resource of biochemical reactions

Rafael Alcántara(SIB Swiss Institute of Bioinformatics), Kristian B. Axelsen(SIB Swiss Institute of Bioinformatics), Anne Morgat(Université Claude Bernard Lyon 1), Eugeni Belda(SIB Swiss Institute of Bioinformatics), Elisabeth Coudert(SIB Swiss Institute of Bioinformatics), Alan Bridge(SIB Swiss Institute of Bioinformatics), Hong Cao(SIB Swiss Institute of Bioinformatics), Paula de Matos(SIB Swiss Institute of Bioinformatics), Marcus Ennis(SIB Swiss Institute of Bioinformatics), Steve Turner(SIB Swiss Institute of Bioinformatics), Gareth Owen(SIB Swiss Institute of Bioinformatics), Lydie Bougueleret(SIB Swiss Institute of Bioinformatics), Ioannis Xénarios(SIB Swiss Institute of Bioinformatics), Christoph Steinbeck(SIB Swiss Institute of Bioinformatics)
Nucleic Acids Research
November 30, 2011
10.1093/nar/gkr1126
Cited by 118Open Access
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Abstract

Rhea (http://www.ebi.ac.uk/rhea) is a comprehensive resource of expert-curated biochemical reactions. Rhea provides a non-redundant set of chemical transformations for use in a broad spectrum of applications, including metabolic network reconstruction and pathway inference. Rhea includes enzyme-catalyzed reactions (covering the IUBMB Enzyme Nomenclature list), transport reactions and spontaneously occurring reactions. Rhea reactions are described using chemical species from the Chemical Entities of Biological Interest ontology (ChEBI) and are stoichiometrically balanced for mass and charge. They are extensively manually curated with links to source literature and other public resources on metabolism including enzyme and pathway databases. This cross-referencing facilitates the mapping and reconciliation of common reactions and compounds between distinct resources, which is a common first step in the reconstruction of genome scale metabolic networks and models.

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