P450-Mediated O-Demethylated Metabolite Is Responsible for Rat Hepatobiliary Toxicity of Pyridyltriazine-Containing PI3K Inhibitors

Raju Subramanian(Gilead Sciences (United States)), Hervé Lebrec(Amgen (United States)), Dan Branstetter(Amgen (United States)), Ronya Primack(Amgen (United States)), Nancy Everds(Amgen (United States)), Mark H. Norman(Amgen (United States)), Mylo Wagner(Amgen (United States)), Irene Soto(Amgen (United States)), Jian Jiang(Xuzhou Medical College), Divesh Aidasani(Amgen (United States)), Gary L. Skiles, Tian Wu(Guangzhou University of Chinese Medicine), Xiaochun Zhu(Amgen (United States)), Keith Bailey(Amgen (United States)), Markian M. Stec(Amgen (United States))
Toxicological Sciences
August 26, 2014
Cited by 7


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