Prevalence and Genetic Relatedness of Methicillin-Susceptible Staphylococcus aureus Isolates Detected by the Xpert MRSA Nasal Assay
Sophie Arbefeville(University of Iowa), Kunyan Zhang(University of Calgary), J. Kroeger(University of Iowa Health Care), Wanita J. Howard(University of Iowa Health Care), Daniel J. Diekema(University of Iowa Health Care), Sandra S. Richter(Cleveland Clinic)
Cited by 33Open Access
Abstract
Methicillin-susceptible Staphylococcus aureus (MSSA) isolates lacking mecA yet testing positive on the Xpert MRSA assay were recovered from culture for 7.7% of 248 Xpert-positive nasal samples. These "false-positive" Xpert results may be attributed to staphylococcal cassette chromosome (SCC) elements without the mecA gene. Pulsed-field gel electrophoresis (PFGE) analysis revealed a diverse population of MSSA strains.
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