Pyrene‐Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids
Jin Huang(Hunan University), Yanrong Wu(Interface (United States)), Yan Chen(State Key Laboratory of Chemobiosensing and Chemometrics), Zhi Zhu(University of Florida Health), Xiaohai Yang(Hunan University), Chaoyong Yang(Hunan University), Kemin Wang(Hunan University), Weihong Tan(Interface (United States))
Cited by 518
Abstract
Make it a double: Complementary probes with two pyrene labels were engineered for the amplification of a target DNA sequence. In the stem-closed conformation of the probes in the absence of the target, the two pyrene moieties were separated. The target propagated hybridization chain reactions to bring pyrene moieties on neighboring probes close together to form fluorescent pyrene excimers (see picture).
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