Sequential Rhodium/Palladium Catalysis: Enantioselective Formation of Dihydroquinolinones in the Presence of Achiral and Chiral Ligands
Lei Zhang(University of Toronto), Zafar Qureshi(University of Toronto), Lorenzo Sonaglia(University of Toronto), Mark Lautens(University of Toronto)
Cited by 82
Abstract
Compatible combinations of achiral and chiral ligands can be used in rhodium/palladium catalysis to achieve highly enantioselective domino reactions. The difference in rates of catalysis and minimal effects of ligand interference confer control in the domino sequence. The "all-in-one" 1,4-conjugate arylation and C-N cross-coupling through sequential Rh/Pd catalysis provides access to enantioenriched dihydroquinolinone building blocks.
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