Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome
I. Jon Russell(The University of Texas at San Antonio Health Science Center), Malcolm D. Orr(The University of Texas at Austin), Bruce H. Littman(Pfizer (United States)), Gilbert A. Vipraio(The University of Texas at Austin), David Alboukrek(The University of Texas at Austin), Joel Michalek, Yolanda Rebeca Peñaloza López(The University of Texas at Austin), Fane Mackillip(The University of Texas at Austin)
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Abstract
OBJECTIVE: To measure, and seek clinical correlates with, levels of substance P (SP) in the cerebrospinal fluid (CSF) of fibromyalgia syndrome (FMS) patients. METHODS: CSF from 32 FMS patients and 30 normal control subjects was tested for SP by radioimmunoassay. Clinical measures included tender point examination and standardized questionnaires. RESULTS: CSF SP levels were 3-fold higher in FMS patients than in normal controls (P < 0.001), but they correlated only weakly with tenderness found on examination. CONCLUSION: SP is significantly elevated in FMS CSF, but other abnormalities must exist in FMS to more fully explain the symptoms.
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