Comparative Genomics of the Eukaryotes

Gerald M. Rubin(Howard Hughes Medical Institute), Mark Yandell(ID Genomics (United States)), Jennifer R. Wortman(ID Genomics (United States)), George L. Gabor, Miklós, Catherine R. Nelson(University of California, Berkeley), Iswar K. Hariharan(Harvard University Press), Mark Fortini(University of Pennsylvania), Peter W. Li(ID Genomics (United States)), Rolf Apweiler(European Bioinformatics Institute), Wolfgang Fleischmann(European Bioinformatics Institute), J. Michael Cherry(Palo Alto University), Steven Henikoff(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa), Marian Skupski(ID Genomics (United States)), Sima Misra(University of California, Berkeley), Michael Ashburner(European Bioinformatics Institute), Ewan Birney(European Bioinformatics Institute), Mark S. Boguski(National Institutes of Health), Thomas Brody(National Institute of Neurological Disorders and Stroke), Peter Brokstein(University of California, Berkeley), S Celniker(Lawrence Berkeley National Laboratory), Stephen A. Chervitz(China Construction Eighth Engineering Division (China)), David Coates(University of Leeds), Anibal Cravchik(ID Genomics (United States)), Andrei Gabrielian(ID Genomics (United States)), Richard F. Galle(Lawrence Berkeley National Laboratory), William M Gelbart(Harvard University), Reed George(Lawrence Berkeley National Laboratory), Lawrence S.B. Goldstein(Howard Hughes Medical Institute), Fangcheng Gong(ID Genomics (United States)), Ping Guan(ID Genomics (United States)), Nomi L. Harris(Lawrence Berkeley National Laboratory), Bruce A. Hay(California Institute of Technology), Roger A. Hoskins(Lawrence Berkeley National Laboratory), Jiayin Li(ID Genomics (United States)), Zhenya Li(ID Genomics (United States)), Richard O. Hynes(Howard Hughes Medical Institute), Steven J.M. Jones(Genome British Columbia), Peter Kuehl(University of Maryland, Baltimore), Bruno Lemaître(Centre National de la Recherche Scientifique), J. Troy Littleton(IIT@MIT), Deborah K. Morrison(Frederick National Laboratory for Cancer Research), Chris Mungall(Lawrence Berkeley National Laboratory), Patrick H. O’Farrell(University of California, San Francisco), Oxana K. Pickeral(National Institutes of Health), Chris Shue(ID Genomics (United States)), Leslie B. Vosshall(Columbia University), Jiong Zhang(National Institutes of Health), Qi Zhao(ID Genomics (United States)), Xiangqun Zheng-Bradley(ID Genomics (United States)), Fei Zhong(ID Genomics (United States)), Wenyan Zhong(ID Genomics (United States)), Richard A. Gibbs(Baylor College of Medicine), J. Craig Venter(ID Genomics (United States)), Mark D. Adams(ID Genomics (United States)), Suzanna Lewis(University of California, Berkeley)
Science
March 24, 2000
10.1126/science.287.5461.2204
Cited by 1,699Open Access
Full Text

Abstract

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

Related Papers

No related papers found

Powered by citation graph analysis