Widespread predicted nonsense-mediated mRNAdecay of alternatively-spliced transcripts of humannormal and disease genes
Richard E. Green(University of California, Berkeley), Benjamin P. Lewis(University of California System), R. Tyler Hillman, Marco Blanchette(University of California, Berkeley), Liana F. Lareau(University of California, Berkeley), Aaron T. Garnett(University of California, Berkeley), Donald C. Rio(University of California, Berkeley), Steven E. Brenner(University of California System)
Cited by 190
Abstract
We have recently shown that a third of reliably-inferred alternative mRNA isoforms are candidates for nonsense-mediated mRNA decay (NMD), an mRNA surveillance system (Lewis et al., 2003; PROC: Natl Acad. Sci. USA, 100, 189-192). Rather than being translated to yield protein, these transcripts are expected to be degraded and may be subject to regulated unproductive splicing and translation (RUST). Our initial experimental studies are consistent with these predictions and suggest an unappreciated role for NMD in several human diseases.
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