Hypothalamic obesity in weanling rats

Abstract

Bilateral hypothalamic lesions were placed in the ventromedial nuclei of 15 male weanling rats. Nine male littermates were used as controls. Food intake, body weight, and nose-occipital (N-O) length were followed for 90 days. Rats were killed on the 90th postoperative day and stomach weight, body fat content, and femur length were then measured. Although the daily food intake and the rate of body weight gain of the rats with lesions were comparable to those of their controls, all 15 operated rats became obese and their N-O and femur lengths were significantly shorter. It is concluded that hypothalamic obesity of weanling rats is associated with growth impairment.