Ruthenium Half‐Sandwich Complexes Bound to Protein Kinase Pim‐1
J.E. Debreczeni(University of Oxford), Alex N. Bullock(Genomics (United Kingdom)), G. Ekin Atilla(University of Pennsylvania), Douglas S. Williams(University of Pennsylvania), Howard Bregman(University of Pennsylvania), Stefan Knapp(University of Oxford), Eric Meggers(University of Pennsylvania)
Cited by 232
Abstract
Keeping in shape with half a sandwich: The structure of a picomolar organoruthenium inhibitor bound to the ATP-binding site of the protein kinase Pim-1 (see picture) demonstrates that the ruthenium center has solely a structural role in organizing the organic ligands in the three-dimensional receptor space, thus yielding a structure that is complementary in shape and functional group presentation to the active site of Pim-1.
Related Papers
No related papers found
Powered by citation graph analysis