Imaging Transcription in Living Cells
Xavier Darzacq(Centre National de la Recherche Scientifique), Jie Yao(Howard Hughes Medical Institute), Daniel R. Larson(Albert Einstein College of Medicine), Sébastien Causse(Centre National de la Recherche Scientifique), Lana Bosanac(Centre National de la Recherche Scientifique), Valeria de Turris(Albert Einstein College of Medicine), Vera M. Ruda(Centre National de la Recherche Scientifique), Timothée Lionnet(Albert Einstein College of Medicine), Daniel Zenklusen(Albert Einstein College of Medicine), Benjamin Guglielmi(Howard Hughes Medical Institute), Robert Tjian(Howard Hughes Medical Institute), Robert H. Singer(Albert Einstein College of Medicine)
Cited by 120
Abstract
The advent of new technologies for the imaging of living cells has made it possible to determine the properties of transcription, the kinetics of polymerase movement, the association of transcription factors, and the progression of the polymerase on the gene. We report here the current state of the field and the progress necessary to achieve a more complete understanding of the various steps in transcription. Our Consortium is dedicated to developing and implementing the technology to further this understanding.
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