Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation
Jun Tang(Icahn School of Medicine at Mount Sinai), Mark E. Lobatto(Amsterdam UMC Location University of Amsterdam), Laurien Hassing(Amsterdam UMC Location University of Amsterdam), Susanne van der Staay(Amsterdam UMC Location University of Amsterdam), Sarian M. van Rijs(Amsterdam UMC Location University of Amsterdam), Claudia Calcagno(Icahn School of Medicine at Mount Sinai), Mounia S. Braza(Icahn School of Medicine at Mount Sinai), Samantha Baxter(Icahn School of Medicine at Mount Sinai), François Fay(Icahn School of Medicine at Mount Sinai), Brenda L. Sánchez-Gaytán(Icahn School of Medicine at Mount Sinai), Raphaël Duivenvoorden(Amsterdam UMC Location University of Amsterdam), Hendrik B. Sager(Harvard University), Yaritzy M. Astudillo(New York University), Wei Leong(Icahn School of Medicine at Mount Sinai), Sarayu Ramachandran(Icahn School of Medicine at Mount Sinai), Gert Storm(Utrecht University), Carlos Pérez‐Medina(Icahn School of Medicine at Mount Sinai), Thomas Reiner(Memorial Sloan Kettering Cancer Center), David P. Cormode(University of Pennsylvania), Gustav J. Strijkers(Amsterdam UMC Location University of Amsterdam), Erik S.G. Stroes(Amsterdam UMC Location University of Amsterdam), Filip K. Świrski(Harvard University), Matthias Nahrendorf(Harvard University), Edward A. Fisher(New York University), Zahi A. Fayad(Icahn School of Medicine at Mount Sinai), Willem J. M. Mulder(Amsterdam UMC Location University of Amsterdam)
Cited by 227Open Access
Abstract
) with advanced atherosclerotic plaques. This resulted in rapid reduction of plaque inflammation and favorable phenotype remodeling. We then combined this short-term nanoparticle intervention with an eight-week oral statin treatment, and this regimen rapidly reduced and continuously suppressed plaque inflammation. Our results demonstrate that pharmacologically inhibiting local macrophage proliferation can effectively treat inflammation in atherosclerosis.
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