From Sequence to Chromosome: The Tip of the <i>X</i> Chromosome of <i>D. melanogaster</i>

Panayiotis V. Benos(European Bioinformatics Institute), Melanie K. Gatt(University of Dundee), Michael Ashburner(European Bioinformatics Institute), Lee Murphy(Wellcome Sanger Institute), David J. Harris(Wellcome Sanger Institute), Bart Barrell(Wellcome Sanger Institute), Concepción Ferraz(Centre National de la Recherche Scientifique), Sophie Vidal(Centre National de la Recherche Scientifique), Christine Brun(Centre National de la Recherche Scientifique), Jacques Demailles(Centre National de la Recherche Scientifique), Édouard Cadieu(Centre National de la Recherche Scientifique), Stéphane Dréano(Centre National de la Recherche Scientifique), Stéphanie Gloux(Centre National de la Recherche Scientifique), Valérie Lelaure(Centre National de la Recherche Scientifique), Stéphanie Mottier(Centre National de la Recherche Scientifique), Francis Galibert(Centre National de la Recherche Scientifique), Dana Borkova(European Molecular Biology Laboratory), Belén Miñana(European Molecular Biology Laboratory), Fotis C. Kafatos(European Molecular Biology Laboratory), Christos Louis(University of Crete), Inga Sidén‐Kiamos(Foundation for Research and Technology Hellas), Slava Bolshakov(European Molecular Biology Laboratory), George Papagiannakis(Foundation for Research and Technology Hellas), Lefteris Spanos(Foundation for Research and Technology Hellas), Sarah Cox(Foundation for Research and Technology Hellas), Encarnación Madueño(Centro de Biología Molecular Severo Ochoa), Beatriz de Pablos(Centro de Biología Molecular Severo Ochoa), Juan Modolell(Centro de Biología Molecular Severo Ochoa), Annette Peter(Max Planck Institute for Biophysical Chemistry), Petra Schöttler(Max Planck Institute for Biophysical Chemistry), Meike Werner(Max Planck Institute for Biophysical Chemistry), Foteini Mourkioti(Max Planck Institute for Biophysical Chemistry), Nicole Beinert(Max Planck Institute for Biophysical Chemistry), Gordon Dowe(Max Planck Institute for Biophysical Chemistry), Ulrich Schäfer(Max Planck Institute for Biophysical Chemistry), Herbert Jäckle(Max Planck Institute for Biophysical Chemistry), Alain Bucheton(Centre National de la Recherche Scientifique), Deborah M. Callister(University of Dundee), Lorna Campbell(University of Dundee), Areti Darlamitsou(University of Dundee), Nadine S. Henderson(University of Dundee), Paul J. McMillan(University of Dundee), Cathy Salles(University of Dundee), Evelyn Tait(University of Dundee), Phillipe Valenti(University of Dundee), Dominique Robert, Saunders(University of Dundee), David M. Glover(University of Dundee)
Science
March 24, 2000
10.1126/science.287.5461.2220
Cited by 30

Abstract

One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350-base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself.

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