Identical Human Papillomavirus (HPV) Genomic Variants Persist in Recurrent Respiratory Papillomatosis for up to 22 Years
Boštjan J. Kocjan(University of Ljubljana), Nina Gale(University of Ljubljana), Irena Hočevar Boltežar(Ljubljana University Medical Centre), Katja Seme(University of Ljubljana), Kristina Fujs Komloš(University of Ljubljana), Lea Hošnjak(University of Ljubljana), Polona J. Maver(University of Ljubljana), Mateja M. Jelen(University of Ljubljana), Irena Zupanič Pajnič(University of Ljubljana), Jože Balažič(University of Ljubljana), Mario Poljak(University of Ljubljana)
Cited by 44Open Access
Abstract
Seventy initial and 125 follow-up tissue specimens of laryngeal papillomas, obtained from 70 patients who had had recurrent respiratory papillomatosis for from 1-22 years, were investigated for the presence of human papillomavirus (HPV) DNA and HPV E5a, LCR and/or full-length genomic variants. HPV-6 was found in 130/195, HPV-11 in 63/195, and HPV-6/HPV-11 in 2/195 samples. Within 67/70 (95.7%) patients, all follow-up HPV isolates genetically matched completely initial HPV isolate over the highly variable parts of the genome or over the entire genome. Frequent recurrence of laryngeal papillomas is a consequence of long-term persistence of the identical initial HPV genomic variant.
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