A Heat-Sensitive TRP Channel Expressed in Keratinocytes
Andrea Peier(Genomics Institute of the Novartis Research Foundation), Alison J. Reeve(Novartis (United Kingdom)), David A. Andersson(Wolfson Medical Center), Aziz Moqrich(Scripps Research Institute), Taryn J. Earley(Scripps Research Institute), Anne C. Hergarden(Genomics Institute of the Novartis Research Foundation), Gina M. Story(Scripps Research Institute), Sian Colley(Novartis (United Kingdom)), John B. Hogenesch(Genomics Institute of the Novartis Research Foundation), Peter McIntyre(Novartis (United Kingdom)), Stuart Bevan(Wolfson Medical Center), Ardem Patapoutian(Scripps Research Institute)
Cited by 971Open Access
Abstract
Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.
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