Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

the ICGC Prostate Group; Colin S. Cooper; Rosalind A. Eeles; David C. Wedge; Peter Van Loo; Gunes Gundem; Ludmil B. Alexandrov; Bárbara Kremeyer; Adam Butler; Andy G. Lynch; Niedzica Camacho; Charles Massie; Jonathan Kay; Hayley J. Luxton; Sandra E. Edwards; Zsofia Kote‐Jarai; Nening M. Dennis; Sue Merson; Daniel Leongamornlert; Jorge Zamora; Cathy Corbishley; Sarah Thomas; Serena Nik‐Zainal; Manasa Ramakrishna; Sarah O’Meara; Lucy Matthews; Jeremy Clark; Rachel Hurst; Richard Mithen; Robert G. Bristow; Paul C. Boutros; Michael Fraser; Susanna L. Cooke; Keiran Raine; David Jones; Andrew Menzies; Lucy Stebbings; Jon Hinton; Jon W. Teague; Stuart McLaren; Laura Mudie; Claire Hardy; Elizabeth Anderson; Olivia Joseph; Victoria Goody; Ben Robinson; Mark Maddison; Stephen J. Gamble; Christopher Greenman; Daniel M. Berney; Steven Hazell; Naomi Livni; Cyril Fisher; Christopher Ogden; Pardeep Kumar; Alan Thompson; Christopher Woodhouse; David M. Nicol; Erik Mayer; Tim Dudderidge; Nimish Shah; Vincent J. Gnanapragasam; Thierry Voet; Peter J. Campbell; P. Andrew Futreal; Douglas Easton; Anne Y. Warren; Christopher S. Foster; Michael R. Stratton; Hayley C. Whitaker; Ultan McDermott; Daniel S. Brewer; David E. Neal

doi:10.1038/ng.3221

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

the ICGC Prostate Group(University of East Anglia), Colin S. Cooper(University of East Anglia), Rosalind A. Eeles(Royal Marsden NHS Foundation Trust), David C. Wedge(Wellcome Sanger Institute), Peter Van Loo(Cancer Research UK), Gunes Gundem(Wellcome Sanger Institute), Ludmil B. Alexandrov(Wellcome Sanger Institute), Bárbara Kremeyer(Wellcome Sanger Institute), Adam Butler(Cancer Research UK), Andy G. Lynch(Institute of Cancer Research), Niedzica Camacho(Institute of Cancer Research), Charles Massie(Cancer Research UK), Jonathan Kay(Cancer Research UK), Hayley J. Luxton(Institute of Cancer Research), Sandra E. Edwards(Institute of Cancer Research), Zsofia Kote‐Jarai(Royal Marsden NHS Foundation Trust), Nening M. Dennis(Royal Marsden NHS Foundation Trust), Sue Merson(Institute of Cancer Research), Daniel Leongamornlert(Institute of Cancer Research), Jorge Zamora(St George's Hospital), Cathy Corbishley(St George's Hospital), Sarah Thomas(Royal Marsden NHS Foundation Trust), Serena Nik‐Zainal(Wellcome Sanger Institute), Manasa Ramakrishna(Wellcome Sanger Institute), Sarah O’Meara(Institute of Cancer Research), Lucy Matthews(University of East Anglia), Jeremy Clark(University of East Anglia), Rachel Hurst(University of East Anglia), Richard Mithen(University Health Network), Robert G. Bristow(University of Toronto), Paul C. Boutros(Ontario Institute for Cancer Research), Michael Fraser(University of Toronto), Susanna L. Cooke(Wellcome Sanger Institute), Keiran Raine(Wellcome Sanger Institute), David Jones(Wellcome Sanger Institute), Andrew Menzies(Wellcome Sanger Institute), Lucy Stebbings(Wellcome Sanger Institute), Jon Hinton(Wellcome Sanger Institute), Jon W. Teague(Wellcome Sanger Institute), Stuart McLaren(Wellcome Sanger Institute), Laura Mudie(Wellcome Sanger Institute), Claire Hardy(Wellcome Sanger Institute), Elizabeth Anderson(Wellcome Sanger Institute), Olivia Joseph(Wellcome Sanger Institute), Victoria Goody(Wellcome Sanger Institute), Ben Robinson(Wellcome Sanger Institute), Mark Maddison(Wellcome Sanger Institute), Stephen J. Gamble(University of East Anglia), Christopher Greenman(University of East Anglia), Daniel M. Berney(Royal Marsden NHS Foundation Trust), Steven Hazell(Royal Marsden NHS Foundation Trust), Naomi Livni(Royal Marsden NHS Foundation Trust), Cyril Fisher(Royal Marsden NHS Foundation Trust), Christopher Ogden(Royal Marsden NHS Foundation Trust), Pardeep Kumar(Royal Marsden NHS Foundation Trust), Alan Thompson(Royal Marsden NHS Foundation Trust), Christopher Woodhouse(Royal Marsden NHS Foundation Trust), David M. Nicol(Royal Marsden NHS Foundation Trust), Erik Mayer(Royal Marsden NHS Foundation Trust), Tim Dudderidge(Royal Marsden NHS Foundation Trust), Nimish Shah(Cancer Research UK), Vincent J. Gnanapragasam(Cancer Research UK), Thierry Voet(Wellcome Sanger Institute), Peter J. Campbell(Wellcome Sanger Institute), P. Andrew Futreal(University of Cambridge), Douglas Easton(University of Cambridge), Anne Y. Warren(University of Liverpool), Christopher S. Foster(University of Liverpool), Michael R. Stratton(Cancer Research UK), Hayley C. Whitaker(Cancer Research UK), Ultan McDermott(Wellcome Sanger Institute), Daniel S. Brewer(University of East Anglia), David E. Neal(University of Cambridge)

Nature Genetics

March 2, 2015

10.1038/ng.3221

Cited by 457Open Access

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