diXa: a data infrastructure for chemical safety assessment

Diana M. Hendrickx(European Bioinformatics Institute), Hugo J.W.L. Aerts(European Bioinformatics Institute), Florian Caiment(European Bioinformatics Institute), Dominic A. Clark(European Bioinformatics Institute), Timothy M. D. Ebbels(European Bioinformatics Institute), Chris T. Evelo(European Bioinformatics Institute), Hans Gmuender(European Bioinformatics Institute), Dennie G.A.J. Hebels(European Bioinformatics Institute), Ralf Herwig(European Bioinformatics Institute), Jürgen Hescheler(European Bioinformatics Institute), Danyel Jennen(European Bioinformatics Institute), Marlon J. Jetten(European Bioinformatics Institute), Stathis Kanterakis(European Bioinformatics Institute), Hector C. Keun(European Bioinformatics Institute), Vera Matser(European Bioinformatics Institute), John P. Overington(European Bioinformatics Institute), Ekaterina Pilicheva(European Bioinformatics Institute), Uğis Sarkans(European Bioinformatics Institute), Marcelo P. Segura-Lepe(European Bioinformatics Institute), Isaia Sotiriadou(European Bioinformatics Institute), Timo Wittenberger(European Bioinformatics Institute), Clemens Wittwehr(European Bioinformatics Institute), Antonella Zanzi(European Bioinformatics Institute), Jos Kleinjans(European Bioinformatics Institute)
Bioinformatics
December 12, 2014
10.1093/bioinformatics/btu827
Cited by 35Open Access
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Abstract

MOTIVATION: The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available. RESULTS: The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal. AVAILABILITY AND IMPLEMENTATION: http://www.dixa-fp7.eu CONTACT: d.hendrickx@maastrichtuniversity.nl; info@dixa-fp7.eu SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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