Positive Correlation between Virulence of <i>Pseudomonas aeruginosa</i> Mutants in Mice and Insects
Georg Jander(Harvard University), Laurence G. Rahme(Harvard University), Frederick M. Ausubel(Harvard University)
Cited by 534Open Access
Abstract
Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa.
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