MINT, the molecular interaction database: 2012 update

Luana Licata(University of Rome Tor Vergata), Leonardo Briganti(Istituti di Ricovero e Cura a Carattere Scientifico), Daniele Peluso(Istituti di Ricovero e Cura a Carattere Scientifico), Livia Perfetto(Istituti di Ricovero e Cura a Carattere Scientifico), Marta Iannuccelli(Istituti di Ricovero e Cura a Carattere Scientifico), Eugenia Galeota(Istituti di Ricovero e Cura a Carattere Scientifico), Francesca Sacco(University of Rome Tor Vergata), Anita Palma(Istituti di Ricovero e Cura a Carattere Scientifico), Aurelio Pio Nardozza(Fondazione Santa Lucia), Elena Santonico(Istituti di Ricovero e Cura a Carattere Scientifico), Luisa Castagnoli(Fondazione Santa Lucia), Gianni Cesareni(Fondazione Santa Lucia)
Nucleic Acids Research
November 16, 2011
10.1093/nar/gkr930
Cited by 1,080Open Access
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Abstract

The Molecular INTeraction Database (MINT, http://mint.bio.uniroma2.it/mint/) is a public repository for protein-protein interactions (PPI) reported in peer-reviewed journals. The database grows steadily over the years and at September 2011 contains approximately 235,000 binary interactions captured from over 4750 publications. The web interface allows the users to search, visualize and download interactions data. MINT is one of the members of the International Molecular Exchange consortium (IMEx) and adopts the Molecular Interaction Ontology of the Proteomics Standard Initiative (PSI-MI) standards for curation and data exchange. MINT data are freely accessible and downloadable at http://mint.bio.uniroma2.it/mint/download.do. We report here the growth of the database, the major changes in curation policy and a new algorithm to assign a confidence to each interaction.

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