Antigenic and Genetic Properties of Viruses Linked to Hemorrhagic Fever with Renal Syndrome
Connie S. Schmaljohn(United States Army Medical Research Institute of Infectious Diseases), Sherman E. Hasty(United States Army Medical Research Institute of Infectious Diseases), Joel M. Dalrymple(United States Army Medical Research Institute of Infectious Diseases), James W. LeDuc(United States Army Medical Research Institute of Infectious Diseases), H. W. Lee(Korea University), C.‐H. von Bonsdorff(University of Helsinki), M Brummer‐Korvenkontio(University of Helsinki), Antti Vaheri(University of Helsinki), Theodore F. Tsai(Centers for Disease Control and Prevention), Helen L. Regnery(Centers for Disease Control and Prevention), Dmitry Goldgaber(National Institute of Neurological Disorders and Stroke), P. W. Lee(National Institute of Neurological Disorders and Stroke)
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Abstract
Hemorrhagic fever with renal syndrome (HFRS) comprises a variety of clinically similar diseases of viral etiology that are endemic to and sporadically epidemic throughout the Eurasian continent and Japan. Although HFRS has not been reported in North America, viruses that are antigenically similar to HFRS agents were recently isolated from rodents in the United States. Examination and comparison of eight representative isolates from endemic disease areas and from regions with no known associated HFRS indicate that these viruses represent a new and unique group that constitutes a separate genus in the Bunyaviridae family of animal viruses.
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