Enantioselective Dichlorination of Allylic Alcohols
K. C. Nicolaou(Scripps Research Institute), Nicholas L. Simmons(University of California, San Diego), Yongcheng Ying(University of California, San Diego), Philipp Heretsch(Scripps Research Institute), Jason S. Chen(University of California, San Diego)
Cited by 240
Abstract
The development of an enantioselective allylic alcohol dichlorination catalyzed by dimeric cinchona alkaloid derivatives and employing aryl iododichlorides as chlorine sources is reported. Reaction optimization, exploration of the substrate scope, and a model for stereoinduction are presented.
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