Antioxidant and antiproliferative activity of<i>Hypericum hircinum</i>L. subsp.<i>majus</i>(Aiton) N. Robson essential oil

Luana Quassinti(Università di Camerino), Giulio Lupidi(Università di Camerino), Filippo Maggi(Università di Camerino), Gianni Sagratini(Università di Camerino), Fabrizio Papa(Università di Camerino), Sauro Vittori(Università di Camerino), Armandodoriano Bianco(Sapienza University of Rome), Massimo Bramucci(Università di Camerino)
Natural Product Research
April 5, 2012
10.1080/14786419.2012.677044
Cited by 85

Abstract

This study was undertaken to assess the antioxidant and antiproliferative potential of the essential oil of Hypericum hircinum L. subsp. majus (Aiton) N. Robson. Analysis of the oil composition revealed that sesquiterpene hydrocarbons (69.3%) dominate, cis-β-guaiene, δ-selinene and (E)-caryophyllene being the most representative. Significant values of antioxidant activity were found using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging assays. The essential oil revealed antiproliferative activity as evaluated on human glioblastoma (T98G), human prostatic adenocarcinoma (PC3), human squamous carcinoma (A431) and mouse melanoma (B16-F1) tumour cell lines by MTT assay.

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