Diketopiperazines from the <i>Cordyceps</i>-Colonizing Fungus <i>Epicoccum nigrum</i>
Huijuan Guo(Wuhan Institute of Virology), Bing‐Da Sun(Wuhan Institute of Virology), Hao Gao(Chinese Academy of Sciences), Xu‐Lin Chen(Wuhan Institute of Virology), Shuchun Liu(Chinese Academy of Sciences), Xin‐Sheng Yao(Chinese Academy of Sciences), Xingzhong Liu(Chinese Academy of Sciences), Yongsheng Che(Chinese Academy of Sciences)
Cited by 114
Abstract
New diketopiperazines, epicoccins E-H (1-4) and diphenylalazines A (5) and B (6), have been isolated from the solid-substrate fermentation culture of the Cordyceps-colonizing fungus Epicoccum nigrum. The structures of 1-6 were determined primarily by NMR experiments, and the structure of 1 was confirmed by X-ray crystallography. The absolute configurations of 3 and 5 were assigned using the modified Mosher (3) and Marfey's (5) methods, respectively. Compounds 3-5 showed inhibitory effects on HIV-1 replication in C8166 cells.
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