A Deletion Truncating the Gonadotropin-Releasing Hormone Gene Is Responsible for Hypogonadism in the <i>hpg</i> Mouse
Anthony J. Mason(Atotech (United States)), Joel S. Hayflick(Atotech (United States)), R. Thomas Zoeller(National Institute of Mental Health), W. Scott Young(National Institute of Mental Health), Heidi Phillips(University of California, San Francisco), Károly Nikolics(Atotech (United States)), Peter H. Seeburg(Max Planck Society)
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Abstract
Hereditary hypogonadism in the hypogonadal (hpg) mouse is caused by a deletional mutation of at least 33.5 kilobases encompassing the distal half of the gene for the common biosynthetic precursor of gonadotropin-releasing hormone (GnRH) and GnRH-associated peptide (GAP). The partially deleted gene is transcriptionally active as revealed by in situ hybridization histochemistry of hpg hypothalamic tissue sections, but immunocytochemical analysis failed to show the presence of antigen corresponding to any part of the precursor protein.
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