The Role of Interleukin-6 in Mucosal IgA Antibody Responses in Vivo
Alistair J. Ramsay(Australian National University), Alan J. Husband(The University of Sydney), lan A. Ramshaw(Australian National University), Shisan Bao(The University of Sydney), Klaus I. Matthaei(Australian National University), Georges Koehler(Max Planck Institute of Immunobiology and Epigenetics), Manfred Köpf(Max Planck Institute of Immunobiology and Epigenetics)
Cited by 455
Abstract
In mice with targeted disruption of the gene that encodes interleukin-6 (IL-6), greatly reduced numbers of immunoglobulin A (IgA)-producing cells were observed at mucosae and grossly deficient local antibody responses were recorded after mucosal challenge with either ovalbumin or vaccinia virus. The IgA response in the lungs was completely restored after intranasal infection with recombinant vaccinia viruses engineered to express IL-6. These findings demonstrate a critical role for IL-6 in vivo in the development of local IgA antibody responses and illustrate the effectiveness of vector-directed cytokine gene therapy.
Related Papers
No related papers found
Powered by citation graph analysis