HTSstation: A Web Application and Open-Access Libraries for High-Throughput Sequencing Data Analysis

Fabrice David(École Polytechnique Fédérale de Lausanne), Julien Delafontaine(École Polytechnique Fédérale de Lausanne), Solenne Carat(École Polytechnique Fédérale de Lausanne), Frederick J. Ross(École Polytechnique Fédérale de Lausanne), Grégory Lefebvre(École Polytechnique Fédérale de Lausanne), Yohan Jarosz(École Polytechnique Fédérale de Lausanne), Lucas Sinclair(École Polytechnique Fédérale de Lausanne), Daan Noordermeer(École Polytechnique Fédérale de Lausanne), Jacques Rougemont(École Polytechnique Fédérale de Lausanne), Marion Leleu(SIB Swiss Institute of Bioinformatics)
PLoS ONE
January 27, 2014
10.1371/journal.pone.0085879
Cited by 117Open Access
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Abstract

The HTSstation analysis portal is a suite of simple web forms coupled to modular analysis pipelines for various applications of High-Throughput Sequencing including ChIP-seq, RNA-seq, 4C-seq and re-sequencing. HTSstation offers biologists the possibility to rapidly investigate their HTS data using an intuitive web application with heuristically pre-defined parameters. A number of open-source software components have been implemented and can be used to build, configure and run HTS analysis pipelines reactively. Besides, our programming framework empowers developers with the possibility to design their own workflows and integrate additional third-party software. The HTSstation web application is accessible at http://htsstation.epfl.ch.

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