Novel Arylsulfoanilide−Oxindole Hybrid as an Anticancer Agent That Inhibits Translation Initiation
Amarnath Natarajan(Harvard University), Yuhong Guo(Harvard University), Frederick Harbinski(Harvard University), Yun-Hua Fan(Harvard University), Han Chen(Harvard University), Lia Luus(Harvard University), Jana Diercks(Harvard University), Hüseyin Aktaş(Harvard University), Michael Chorev(Harvard University), José A. Halperin(Harvard University)
Cited by 186
Abstract
Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca(2+) stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay. Incorporating the substitution pattern of the best arylsulfoanilides onto the 3-phenyloxindole scaffold resulted in a potent arylsulfoanilide-oxindole hybrid, 27. Compound 27 inhibits cancer cell growth by partial depletion of intracellular Ca(2+) stores and phosphorylation of eIF2alpha.
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