Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site
Manuel Nieto‐Sampedro(University of California, Irvine), Ellen R. Lewis(University of California, Irvine), Carl W. Cotman(University of California, Irvine), Marston Manthorpe(University of California San Diego), Stephen D. Skaper(University of California San Diego), G. Barbin(University of California San Diego), Frank M. Longo(University of California San Diego), Silvio Varon(University of California San Diego)
Cited by 475
Abstract
A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.
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