A gene map of the human genome.

Greg Schuler(National Institutes of Health), Mark S. Boguski(National Institutes of Health), Thomas J. Hudson(Stanford University), Lester Hui(Massachusetts Institute of Technology), Junli Ma, Andrew B. Castle, Xiaoyun Wu(University of Oxford), Jeremy De Silva(Wellcome Trust), H. C. Nusbaum(Stanford University), B B Birren(Stanford University), D K Slonim, Steve Rozen(Massachusetts Institute of Technology), Lincoln Stein, David C. Page(Massachusetts Institute of Technology), Eric S. Lander, Elizabeth A. Stewart(Stanford University), Amita Aggarwal, E Bajorek(Stanford University), Shannon D. Brady(University of Oxford), S Chu, N. Fang, David Hadley, Mark Harris, S. Hussain, J. R. Hudson
PubMed
October 25, 1996
Cited by 971

Abstract

The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/.

Related Papers

A comprehensive genetic map of the human genome based on 5,264 microsatellites
Colette Dib, Sabine Fauré, Cécile Fizames et al.|Nature|1996|3k
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
Richard Fishel, Mary Kay Lescoe, Manchanahalli R. Satyanarayana Rao et al.|Cell|1993|2.9k
Mutation of a <i>mutL</i> Homolog in Hereditary Colon Cancer
Nickolas Papadopoulos, Nicholas C. Nicolaides, Ying-Fei Wei et al.|Science|1994|1.8k
Identification of protein coding regions by database similarity search
Warren Gish, David J. States|Nature Genetics|1993|1.7k
Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
Rita Shiang, Leslie M. Thompson, Yazhen Zhu et al.|Cell|1994|1.3k