Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases
Richard T. Johnson(Johns Hopkins University), Donald S. Burke(Armed Forces Research Institute of Medical Science), Michael R. Elwell(Armed Forces Research Institute of Medical Science), C.J. Leake(University of London), Ananda Nisalak(Armed Forces Research Institute of Medical Science), Charles H. Hoke(Armed Forces Research Institute of Medical Science), Wanida Lorsomrudee
Cited by 231
Abstract
The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.
Related Papers
No related papers found
Powered by citation graph analysis