Nanostructured Hydrogels for Three‐Dimensional Cell Culture Through Self‐Assembly of Fluorenylmethoxycarbonyl–Dipeptides
Vineetha Jayawarna(International Union of Pure and Applied Chemistry), Mohd Sajid Ali(University of Manchester), Thomas A. Jowitt(University of Manchester), Aline F. Miller(University of Manchester), Alberto Saiani(University of Manchester), Julie E. Gough(University of Manchester), Rein V. Ulijn(International Union of Pure and Applied Chemistry)
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Abstract
A number of short peptide amphiphiles consisting of dipeptides linked to fluorenylmethoxycarbonyl spontaneously form fibrous hydrogels under physiological conditions (see figure). The structural and physical properties of these gels are dictated by the amino acid sequence of the peptide building blocks, and the gels support the three-dimensional cell culture of chondrocytes.
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