Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release
Xiangyang Zhu(East China University of Science and Technology), Jinlou Gu(East China University of Science and Technology), Yao Wang(East China University of Science and Technology), Bing Li(East China University of Science and Technology), Yongsheng Li(East China University of Science and Technology), Wenru Zhao(East China University of Science and Technology), Jianlin Shi(East China University of Science and Technology)
Cited by 297
Abstract
Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr-O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.
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