Transcription of Novel Open Reading Frames of AIDS Retrovirus During Infection of Lymphocytes
Arnold B. Rabson(National Institute of Allergy and Infectious Diseases), Daryl Daugherty(National Institute of Allergy and Infectious Diseases), Sundararajan Venkatesan(National Institute of Allergy and Infectious Diseases), Kim E. Boulukos(National Institute of Allergy and Infectious Diseases), S Benn(National Institute of Allergy and Infectious Diseases), Thomas M. Folks(National Institute of Allergy and Infectious Diseases), Paul Feorino(Centers for Disease Control and Prevention), Malcolm A. Martin(National Institute of Allergy and Infectious Diseases)
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Abstract
The retrovirus frequently isolated from patients with the acquired immune deficiency syndrome (AIDS) has two novel open reading frames previously designated "A" and "B." The "A" region was found to be specifically expressed as polyadenylated RNA's of 5.5 and 5.0 kilobases in infected cells. The "B" region was expressed as 1.8- to 2.0-kilobase RNA species. Additional full-length and spliced messenger RNA's of the env region were also identified.