<i>In vitro</i> and <i>in vivo</i> two-photon luminescence imaging of single gold nanorods

Haifeng Wang(Purdue University West Lafayette), Terry B. Huff(Purdue University West Lafayette), Daniel A. Zweifel(Purdue University West Lafayette), Wei He(Purdue University West Lafayette), Philip S. Low(Houston Methodist), Alexander Wei(Purdue University West Lafayette), Ji‐Xin Cheng(Purdue University West Lafayette)
Proceedings of the National Academy of Sciences
October 20, 2005
10.1073/pnas.0504892102
Cited by 944Open Access
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Abstract

Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a cos(4) dependence on the incident polarization. The TPL excitation spectrum can be superimposed onto the longitudinal plasmon band, indicating a plasmon-enhanced two-photon absorption cross section. The TPL signal from a single nanorod is 58 times that of the two-photon fluorescence signal from a single rhodamine molecule. The application of gold nanorods as TPL imaging agents is demonstrated by in vivo imaging of single nanorods flowing in mouse ear blood vessels.

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