Molecular mimicry between GQ<sub>1b</sub> ganglioside and lipopolysaccharides of <i>Campylobacter jejuni</i> isolated from patients with Fisher's syndrome
Nobuhiro Yuki(Tokyo Medical and Dental University), T. Taki(Tokyo Medical and Dental University), Masaki Takahashi(Tokyo Metropolitan Institute of Public Health), Kosuke Saito(Tokyo Metropolitan Institute of Public Health), Hiide Yoshino(Tokyo Medical and Dental University), T Tai(Tokyo Metropolitan Institute of Medical Science), Setsuko Handa(Tokyo Medical and Dental University), T. Miyatake(Tokyo Medical and Dental University)
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Abstract
We isolated Campylobacter jejuni from 2 patients with Fisher's syndrome subsequent to enteritis. Crude lipopolysaccharide fractions were extracted from the bacteria and separated by thin-layer chromatography. Monoclonal antibodies to GQ1b ganglioside (GMR13 and 7F5) reacted with both lipopolysaccharide fractions, indicating that the lipopolysaccharides bear the GQ1b epitope. This is the first report of molecular mimicry between neural tissue components and the antecedent infectious agents of Fisher's syndrome.
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